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A powerful blast struck on Monday inside a mosque in the northwestern Pakistani city of Peshawar, killing more than 18 people and wounding more than 70 worshippers, officials said.
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An opposition lawmaker and brother of a disgraced former prime minister appears as a leading contender to replace Khan.
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The nation's politics was thrust into disarray after Prime Minister Imran Khan dissolved parliament ahead of a vote on a no-confidence motion in which he was widely expected to lose.
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The bombing was the latest act of violence in majority Sunni Muslim Pakistan, where minority Shiite Muslims have come under repeated attacks.
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The epicenter of the 5.9 magnitude quake was about 15 kilometers north-northeast of Harnai in Baluchistan province, according to the U.S. Geological Survey.
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In his first tweet of the new year, the president said Islamabad had been playing U.S. leaders for fools by taking billions in foreign aid and continuing to harbor Afghan extremists.